No single city, no group of cities has that population. The TOP 10 cities in the US have a combined population of 28 million. Out of 328. That’s roughly 8% of the population.
If you add up EVERY SINGLE CITY with more than 100,000 people in it (Which is 311 cities), that’s still only 94 million. 28% of the US population.
So this idea that the popular vote would give power to just a few cities isn’t supported by the facts.
On the other hand: Two-thirds (273 of 399) of the general-election campaign events in the 2016 presidential race were in just 6 states(Florida, North Carolina, Pennsylvania, Ohio, Virginia, and Michigan). 94% of the 2016 events (375 of the 399) were in 12 states. While 24 States received 0 visits. Because of the winner-takes-all Electoral College system, candidates can ignore any state that is “safe” and instead completely focus on big cities in swing states.